En-ROADS currently runs on a laptop or desktop computer with a modern web browser, as well as iPads and other similar tablet devices. At the moment, En-ROADS does not include a mobile-optimized user interface, so it cannot be used on iPhone, Android, or other phone-sized devices.

Browsers that support En-ROADS include Chrome 57+, Firefox 52+, Safari 11+, Brave 1.0, and Microsoft Edge 16+. Internet Explorer is not supported.

Climate Interactive has tested En-ROADS using the above browsers on macOS (10.14+), Windows 10, Linux, and ChromeOS (Chromebooks).